纳洛酮治疗新生儿缺氧缺血性脑病疗效分析(1)
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[摘要] 目的 分析纳洛酮治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。 方法 将本科收治的44例HIE患儿随机分为两组，其中对照组21例采用常规治疗方法，观察组23例在对照组治疗的基础上静脉滴注盐酸纳洛酮注射液，比较两组患儿机体、神经功能恢复时间、临床疗效和神经行为测定(NBNA)分数。 结果 观察组机体和神经功能恢复时间显著短于对照组(P < 0.05)；临床疗效和神经行为测定(NBNA)分数显著高于对照组(P < 0.05)。 结论 纳洛酮治疗新生儿缺氧缺血性脑病临床安全、疗效满意。
[关键词] 纳洛酮；新生儿；缺氧缺血性脑病；疗效分析
[中图分类号] R722.1 [文献标识码] A [文章编号] 1674—4721(2012)09(c)—0077—02
Analysis of the clinical efficacy of naloxone in the treatment of neonatal hypoxic—ischemic encephalopathy
CUI Huijuan
Department of Pediatric， Yankuang Group General Hospital in Shandong Province， Zoucheng 273500， China
[Abstract] Objective To analyze the clinical efficacy of naloxone in the treatment of neonatal hypoxic—ischemic encephalopathy (HIE). Methods Forty—four cases of newborns with HIE were randomly divided into two groups， patients of the control group underwent conventional treatment， while patients of the observation group were given naloxone treatment on basis of conventional treatment. The recovery time of the body and neurological function， the clinical efficacy and the scores of NBNA were compared between two groups. Results The body and nerve function recovery time of the observation group was significantly shorter than that of the control group (P < 0.05)， and clinical efficacy and neurobehavioral assessment (NBNA) score was significantly higher than that of the control group (P < 0.05). Conclusion Naloxone is efficient and safe in treatment of HIE.
[Key words] Naloxone； Newborns； Hypoxic—ischemic encephalopathy； Analysis of the clinical efficacy
新生儿缺氧缺血性脑病(HIE)是新生儿临床常见严重疾病之一，经调查早产儿发病率明显高于足月儿，主要病因是新生儿脑局部血液减少，脑血流自动调节功能破坏而致脑缺氧缺血性坏死[1]。HIE发病进程复杂，伴随呼吸系统、循环系统及消化系统等多重并发症，可介导多种脏器损伤，并直接产生神经毒性导致脑组织不可逆坏死。本院对部分HIE患儿行纳洛酮治疗，疗效满意，报道如下：
1 资料与方法
1.1 一般资料
研究对象为本院儿科2009年12月～2011年6月收治的44例新生儿HIE患者，符合《新生儿缺氧缺血性脑病诊断依据和临床分度标准》[2]，患儿出生时均有窒息史，发病48 h内入院，临床症状包括兴奋、嗜睡、肌张力降低、消化功能紊乱等 ......
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